1-(3,4-Dichlorophenethyl)-4-methylpiperazine dihydrochloride
BD 1063 Dihydrochloride
CAS: 206996-13-6
Molecular Formula: C13H20Cl4N2
1-(3,4-Dichlorophenethyl)-4-methylpiperazine dihydrochloride - Names and Identifiers
1-(3,4-Dichlorophenethyl)-4-methylpiperazine dihydrochloride - Physico-chemical Properties
| Molecular Formula | C13H20Cl4N2 |
| Molar Mass | 346.1233 |
| Solubility | H2O: >15mg/mL |
| Appearance | powder |
| Color | white to beige |
| Storage Condition | room temp |
| Stability | Stable for 1 year from date of purchase as supplied. Solutions in distilled water may be stored at -20°C for up to 3 months. |
| In vivo study | BD1063 dose-dependently reduces ethanol self-administration in sP rats (3.3-11 mg/kg) and withdrawn, dependent Wistar rats (4-11 mg/kg) at doses that does not modify mean ethanol self-administration in non-dependent Wistar controls. BD1063 also reduces the breakpoints of sP rats to work for ethanol under a progressive-ratio reinforcement schedule. BD1063 dose-dependently reduces binge-like eating and the regularity of food responding, and blocks the increased eating rate in Palatable rats. In the light/dark conflict test, BD1063 antagonizes the increased time spent in the aversive compartment and the increased intake of the palatable diet, without affecting motor activity. The administration of BD1063 30 minutes before each paclitaxel dose prevents the development of cold and mechanical allodynia in WT mice. Moreover, the acute administration of BD1063 dose dependently reverses both types of paclitaxel-induced allodynia. |
1-(3,4-Dichlorophenethyl)-4-methylpiperazine dihydrochloride - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | 36 - Irritating to the eyes |
| Safety Description | 26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. |
| WGK Germany | 3 |
1-(3,4-Dichlorophenethyl)-4-methylpiperazine dihydrochloride - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 2.889 ml | 14.446 ml | 28.892 ml |
| 5 mM | 0.578 ml | 2.889 ml | 5.778 ml |
| 10 mM | 0.289 ml | 1.445 ml | 2.889 ml |
| 5 mM | 0.058 ml | 0.289 ml | 0.578 ml |
Last Update：2024-01-02 23:10:35
1-(3,4-Dichlorophenethyl)-4-methylpiperazine dihydrochloride - Reference Information
| biological activity | BD1063 2HCL (BD1063 dihydrochloride) is a potent and selective sigma-1 receptor (↑1r) antagonist, the corresponding Ki value was 4.43 nM. |
| Target | Value |
| σ1R (Cell-free assay) | 4.43 nM(Ki) |
| purpose | The novel **-receptor ligands eurotransmitter angiists. |
Last Update：2024-04-09 19:05:16
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Spot supply
Product Name: BD 1063 Dihydrochloride Visit Supplier Webpage Request for quotationCAS: 206996-13-6
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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